УДК 575.224.2

Концевая И.С. Николаевский В.В. Макурина О.Н.

РАСПРОСТРАНЕННОСТЬ ПОЛИМОРФИЗМОВ В ГЕНАХ, АССОЦИИРОВАННЫХ С ВИРУЛЕНТНОСТЬЮ, СРЕДИ ШТАММОВ MYCOBACTERIUM TUBERCULOSIS В САМАРСКОЙ ОБЛАСТИ

Аннотация. В работе рассмотрена распространенность полиморфизмов в генах Mycobacterium tuberculosis, ассоциированных с вирулентностью, их связь с генетическими группами, кластерами штаммов и лекарственной чувствительностью. Обнаружены ассоциации между полиморфизмами в гене plcA и рядом кластеров семейства штаммов LAM, в генах dosT и pks15/1 и семейством Beijing, а также в гене lipR с большинством кластеров групп Ghana, Cameroon, Uganda и S. Выявленная взаимосвязь между изученными полиморфизмами и чувствительностью к препаратам носит опосредованный характер.

Ключевые слова: туберкулез, молекулярная эпидемиология, генотипирование, вирулентность, лекарственная устойчивость.;

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